3ovu
From Proteopedia
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| - | [[Image:3ovu.png|left|200px]] | ||
| - | + | ==Crystal Structure of Human Alpha-Haemoglobin Complexed with AHSP and the First NEAT Domain of IsdH from Staphylococcus aureus== | |
| - | + | <StructureSection load='3ovu' size='340' side='right'caption='[[3ovu]], [[Resolution|resolution]] 2.83Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3ovu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MSSA476 Staphylococcus aureus subsp. aureus MSSA476]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OVU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> |
| - | [[3ovu]] is a 3 chain structure | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ovu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ovu OCA], [https://pdbe.org/3ovu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ovu RCSB], [https://www.ebi.ac.uk/pdbsum/3ovu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ovu ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AHSP_HUMAN AHSP_HUMAN] Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.<ref>PMID:12066189</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Hemoglobin|Hemoglobin]] | + | *[[Haptoglobin receptor|Haptoglobin receptor]] |
| + | *[[Hemoglobin 3D structures|Hemoglobin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Staphylococcus aureus]] | + | [[Category: Large Structures]] |
| - | [[Category: Caradoc-Davies | + | [[Category: Staphylococcus aureus subsp. aureus MSSA476]] |
| - | [[Category: Gell | + | [[Category: Caradoc-Davies TT]] |
| - | [[Category: Guss | + | [[Category: Gell DA]] |
| - | [[Category: Jacques | + | [[Category: Guss JM]] |
| - | [[Category: Kumar | + | [[Category: Jacques DA]] |
| - | [[Category: Langley | + | [[Category: Krishna Kumar K]] |
| - | [[Category: Mackay | + | [[Category: Langley DB]] |
| - | + | [[Category: Mackay JP]] | |
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Current revision
Crystal Structure of Human Alpha-Haemoglobin Complexed with AHSP and the First NEAT Domain of IsdH from Staphylococcus aureus
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