1a6s

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[[Image:1a6s.png|left|200px]]
 
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{{STRUCTURE_1a6s| PDB=1a6s | SCENE= }}
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==M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES==
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<StructureSection load='1a6s' size='340' side='right'caption='[[1a6s]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1a6s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus_-_Prague_C Rous sarcoma virus - Prague C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A6S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6s OCA], [https://pdbe.org/1a6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a6s RCSB], [https://www.ebi.ac.uk/pdbsum/1a6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a6s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/1a6s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a6s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A biologically active construct of the retroviral M domain from the avian Rous sarcoma virus is defined and its solution structure described. This M domain is fully active in budding and infectivity without myristylation. In spite of a sequence homology level that suggests no relationship among M domains and the family of matrix proteins in mammalian retroviruses, the conserved structural elements of a central core allow an M domain sequence motif to be described for all retroviruses. The surface of the M domain has a highly clustered positive patch comprised of sequentially distant residues. An analysis of the backbone dynamics, incorporating rotational anisotropy, is used to estimate the thermodynamics of proposed domain oligomerization.
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===M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES===
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Solution structure and dynamics of the bioactive retroviral M domain from Rous sarcoma virus.,McDonnell JM, Fushman D, Cahill SM, Zhou W, Wolven A, Wilson CB, Nelle TD, Resh MD, Wills J, Cowburn D J Mol Biol. 1998 Jun 19;279(4):921-8. PMID:9642071<ref>PMID:9642071</ref>
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{{ABSTRACT_PUBMED_9642071}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1a6s" style="background-color:#fffaf0;"></div>
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[[1a6s]] is a 1 chain structure of [[Gag polyprotein]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6S OCA].
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==See Also==
==See Also==
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*[[Gag polyprotein|Gag polyprotein]]
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*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009642071</ref><references group="xtra"/>
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__TOC__
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[[Category: Viruses]]
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</StructureSection>
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[[Category: Cahill, S M.]]
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[[Category: Large Structures]]
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[[Category: Cowburn, D.]]
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[[Category: Rous sarcoma virus - Prague C]]
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[[Category: Fushman, D.]]
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[[Category: Cahill SM]]
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[[Category: Mcdonnell, J M.]]
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[[Category: Cowburn D]]
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[[Category: Nelle, T D.]]
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[[Category: Fushman D]]
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[[Category: Resh, M D.]]
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[[Category: Mcdonnell JM]]
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[[Category: Wills, J.]]
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[[Category: Nelle TD]]
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[[Category: Wilson, C B.]]
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[[Category: Resh MD]]
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[[Category: Wolven, A.]]
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[[Category: Wills J]]
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[[Category: Zhou, W.]]
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[[Category: Wilson CB]]
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[[Category: Core protein]]
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[[Category: Wolven A]]
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[[Category: Membrane binding]]
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[[Category: Zhou W]]
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[[Category: Viral protein]]
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[[Category: Virus structure]]
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Current revision

M-DOMAIN FROM GAG POLYPROTEIN OF ROUS SARCOMA VIRUS, NMR, 20 STRUCTURES

PDB ID 1a6s

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