1ucv

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[[Image:1ucv.png|left|200px]]
 
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{{STRUCTURE_1ucv| PDB=1ucv | SCENE= }}
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==Sterile alpha motif (SAM) domain of ephrin type-A receptor 8==
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<StructureSection load='1ucv' size='340' side='right'caption='[[1ucv]]' scene=''>
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===Sterile alpha motif (SAM) domain of ephrin type-A receptor 8===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ucv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UCV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ucv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ucv OCA], [https://pdbe.org/1ucv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ucv RCSB], [https://www.ebi.ac.uk/pdbsum/1ucv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ucv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ucv TOPSAN]</span></td></tr>
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[[1ucv]] is a 1 chain structure of [[Ephrin receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCV OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EPHA8_HUMAN EPHA8_HUMAN] Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uc/1ucv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ucv ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ephrin receptor|Ephrin receptor]]
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*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Transferase]]
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[[Category: Large Structures]]
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[[Category: Goroncy, A.]]
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[[Category: Goroncy A]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Kobayashi, N.]]
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[[Category: Kobayashi N]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Developmental regulation]]
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[[Category: Receptor oligomerization]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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[[Category: Tyrosine kinase]]
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Current revision

Sterile alpha motif (SAM) domain of ephrin type-A receptor 8

PDB ID 1ucv

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