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3g8d

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[[Image:3g8d.png|left|200px]]
 
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{{STRUCTURE_3g8d| PDB=3g8d | SCENE= }}
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==Crystal structure of the biotin carboxylase subunit, E296A mutant, of acetyl-COA carboxylase from Escherichia coli==
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<StructureSection load='3g8d' size='340' side='right'caption='[[3g8d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal structure of the biotin carboxylase subunit, E296A mutant, of acetyl-COA carboxylase from Escherichia coli===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3g8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G8D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19213731}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8d OCA], [https://pdbe.org/3g8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g8d RCSB], [https://www.ebi.ac.uk/pdbsum/3g8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8d ProSAT]</span></td></tr>
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[[3g8d]] is a 2 chain structure of [[Biotin carboxylase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8D OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACCC_ECOLI ACCC_ECOLI] This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g8d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g8d ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Biotin carboxylase|Biotin carboxylase]]
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*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:019213731</ref><references group="xtra"/>
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Chou, C Y.]]
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[[Category: Chou CY]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Yu, L P.]]
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[[Category: Yu LP]]
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[[Category: Active site mutant]]
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[[Category: Atp-binding]]
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[[Category: Atp-grasp]]
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[[Category: Biotin]]
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[[Category: Biotin-dependent]]
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[[Category: Carboxylase]]
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[[Category: Fatty acid biosynthesis]]
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[[Category: Fatty acid synthesis]]
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[[Category: Ligase]]
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[[Category: Lipid synthesis]]
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[[Category: Nucleotide-binding]]
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Current revision

Crystal structure of the biotin carboxylase subunit, E296A mutant, of acetyl-COA carboxylase from Escherichia coli

PDB ID 3g8d

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