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3bo7

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[[Image:3bo7.png|left|200px]]
 
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{{STRUCTURE_3bo7| PDB=3bo7 | SCENE= }}
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==Crystal structure of Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, 541.m00136==
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<StructureSection load='3bo7' size='340' side='right'caption='[[3bo7]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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===Crystal structure of Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, 541.m00136===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3bo7]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Tolypocladium_inflatum Tolypocladium inflatum] and [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BO7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[3bo7]] is a 8 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BO7 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bo7 OCA], [https://pdbe.org/3bo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bo7 RCSB], [https://www.ebi.ac.uk/pdbsum/3bo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bo7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D0VWS5_TOXGO D0VWS5_TOXGO] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).[RuleBase:RU004223]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/3bo7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bo7 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cyclophilin|Cyclophilin]]
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*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Tolypocladium inflatum]]
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Artz, J D.]]
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[[Category: Artz JD]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Hui, R.]]
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[[Category: Hui R]]
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[[Category: Khuu, C.]]
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[[Category: Khuu C]]
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[[Category: Kozieradzki, I.]]
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[[Category: Kozieradzki I]]
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[[Category: Lew, J.]]
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[[Category: Lew J]]
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[[Category: Lin, Y H.]]
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[[Category: Lin YH]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schapira M]]
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[[Category: Schapira, M.]]
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[[Category: Sun X]]
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[[Category: Sun, X.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Wernimont AK]]
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[[Category: Wernimont, A K.]]
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[[Category: Xiao T]]
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[[Category: Xiao, T.]]
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[[Category: Zhao Y]]
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[[Category: Zhao, Y.]]
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[[Category: Cyclophilin]]
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[[Category: Cyclophilin-cyclosporin complex]]
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[[Category: Cyclosporin some]]
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[[Category: Immunosuppressant]]
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[[Category: Isomerase-immunosuppressant complex]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, 541.m00136

PDB ID 3bo7

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