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3o77

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[[Image:3o77.png|left|200px]]
 
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{{STRUCTURE_3o77| PDB=3o77 | SCENE= }}
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==The structure of Ca2+ Sensor (Case-16)==
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<StructureSection load='3o77' size='340' side='right'caption='[[3o77]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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===The structure of Ca2+ Sensor (Case-16)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3o77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O77 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22163646}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CR2:{(4Z)-2-(AMINOMETHYL)-4-[(4-HYDROXYPHENYL)METHYLIDENE]-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>CR2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o77 OCA], [https://pdbe.org/3o77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o77 RCSB], [https://www.ebi.ac.uk/pdbsum/3o77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o77 ProSAT]</span></td></tr>
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[[3o77]] is a 1 chain structure of [[Alyssa Marsico/Sandbox 1]], [[Calmodulin]], [[Devon McCarthy/Sandbox 1]], [[Green Fluorescent Protein]], [[Sandbox104]] and [[User:Joanne Lau/Sandbox 5]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus,_aequorea_victoria,_aequorea_victoria,_homo_sapiens Gallus gallus, aequorea victoria, aequorea victoria, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O77 OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref> [https://www.uniprot.org/uniprot/MYLK_CHICK MYLK_CHICK] Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals.[https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
==See Also==
==See Also==
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*[[Alyssa Marsico/Sandbox 1|Alyssa Marsico/Sandbox 1]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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*[[Calmodulin|Calmodulin]]
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*[[Green Fluorescent Protein 3D structures|Green Fluorescent Protein 3D structures]]
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*[[Devon McCarthy/Sandbox 1|Devon McCarthy/Sandbox 1]]
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== References ==
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*[[Green Fluorescent Protein|Green Fluorescent Protein]]
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<references/>
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*[[Sandbox104|Sandbox104]]
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__TOC__
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*[[User:Joanne Lau/Sandbox 5|User:Joanne Lau/Sandbox 5]]
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</StructureSection>
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[[Category: Aequorea victoria]]
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==Reference==
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[[Category: Gallus gallus]]
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<ref group="xtra">PMID:022163646</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Gallus gallus, aequorea victoria, aequorea victoria, homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Britanova, O V.]]
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[[Category: Britanova OV]]
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[[Category: Chudakov, D M.]]
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[[Category: Chudakov DM]]
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[[Category: Freuler, F.]]
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[[Category: Freuler F]]
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[[Category: Leder, L.]]
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[[Category: Leder L]]
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[[Category: Marsh, M.]]
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[[Category: Marsh M]]
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[[Category: Mayr, L M.]]
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[[Category: Mayr LM]]
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[[Category: Meyerhofer, M.]]
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[[Category: Meyerhofer M]]
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[[Category: Stark, W.]]
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[[Category: Stark W]]
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[[Category: Stettler, T.]]
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[[Category: Stettler T]]
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[[Category: Strukova, L A.]]
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[[Category: Strukova LA]]
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[[Category: Calcium sensor]]
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[[Category: Circular permutated green fluorescent protein]]
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[[Category: Fluorescent calcium indicator protein]]
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[[Category: Fluorescent protein]]
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[[Category: Genetically encoded]]
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[[Category: Gfp calmodulin m13-peptide]]
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[[Category: Gyg naturally modified tripeptide acts as chromophore]]
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[[Category: M13-peptide]]
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Current revision

The structure of Ca2+ Sensor (Case-16)

PDB ID 3o77

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