1p5q

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[[Image:1p5q.png|left|200px]]
 
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{{STRUCTURE_1p5q| PDB=1p5q | SCENE= }}
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==Crystal Structure of FKBP52 C-terminal Domain==
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<StructureSection load='1p5q' size='340' side='right'caption='[[1p5q]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===Crystal Structure of FKBP52 C-terminal Domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p5q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P5Q FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15159550}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p5q OCA], [https://pdbe.org/1p5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p5q RCSB], [https://www.ebi.ac.uk/pdbsum/1p5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p5q ProSAT]</span></td></tr>
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[[1p5q]] is a 3 chain structure of [[FK506 binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5Q OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP4_HUMAN FKBP4_HUMAN] Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.<ref>PMID:1279700</ref> <ref>PMID:1376003</ref> <ref>PMID:2378870</ref> <ref>PMID:19945390</ref> <ref>PMID:21730050</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/1p5q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p5q ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[FK506 binding protein|FK506 binding protein]]
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015159550</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Ding, Y.]]
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[[Category: Ding Y]]
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[[Category: Li, P.]]
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[[Category: Li P]]
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[[Category: Lou, Z.]]
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[[Category: Lou Z]]
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[[Category: Rao, Z.]]
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[[Category: Rao Z]]
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[[Category: Shen, B.]]
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[[Category: Shen B]]
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[[Category: Shu, C.]]
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[[Category: Shu C]]
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[[Category: Wu, B.]]
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[[Category: Wu B]]
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[[Category: Isomerase]]
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Current revision

Crystal Structure of FKBP52 C-terminal Domain

PDB ID 1p5q

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