3p7o
From Proteopedia
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| - | [[Image:3p7o.png|left|200px]] | ||
| - | + | ==Rat Insulin Degrading Enzyme (Insulysin) E111F mutant with two bound peptides== | |
| - | + | <StructureSection load='3p7o' size='340' side='right'caption='[[3p7o]], [[Resolution|resolution]] 2.14Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3p7o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P7O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1423Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p7o OCA], [https://pdbe.org/3p7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p7o RCSB], [https://www.ebi.ac.uk/pdbsum/3p7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p7o ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[3p7o]] is a 3 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/IDE_RAT IDE_RAT] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. | ||
==See Also== | ==See Also== | ||
| - | *[[Insulin- | + | *[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Noinaj | + | [[Category: Noinaj N]] |
| - | [[Category: Rodgers | + | [[Category: Rodgers DW]] |
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| - | + | ||
Current revision
Rat Insulin Degrading Enzyme (Insulysin) E111F mutant with two bound peptides
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