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1qvn

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[[Image:1qvn.png|left|200px]]
 
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{{STRUCTURE_1qvn| PDB=1qvn | SCENE= }}
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==Structure of SP4160 Bound to IL-2 V69A==
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<StructureSection load='1qvn' size='340' side='right'caption='[[1qvn]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===Structure of SP4160 Bound to IL-2 V69A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qvn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QVN FirstGlance]. <br>
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{{ABSTRACT_PUBMED_017032757}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRI:2-GUANIDINO-4-METHYL-PENTANOIC+ACID+[2-(4-{5-[4-(4-ACETYLAMINO-BENZYLOXY)-2,3-DICHLORO-PHENYL]-2-METHYL-2H-PYRAZOL-3-YL}-PIPERIDIN-1-YL)-2-OXO-ETHYL]-AMIDE'>FRI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qvn OCA], [https://pdbe.org/1qvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qvn RCSB], [https://www.ebi.ac.uk/pdbsum/1qvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qvn ProSAT]</span></td></tr>
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[[1qvn]] is a 4 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVN OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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== Function ==
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[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qv/1qvn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qvn ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017032757</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Delano, W L.]]
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[[Category: Large Structures]]
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[[Category: Thanos, C D.]]
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[[Category: Delano WL]]
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[[Category: Wells, J A.]]
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[[Category: Thanos CD]]
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[[Category: Cytokine]]
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[[Category: Wells JA]]
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[[Category: Il-2 small molecule hot spot]]
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Current revision

Structure of SP4160 Bound to IL-2 V69A

PDB ID 1qvn

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