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3nfr
From Proteopedia
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| - | [[Image:3nfr.png|left|200px]] | ||
| - | + | ==Casimiroin analog inhibitor of quinone reductase 2== | |
| - | + | <StructureSection load='3nfr' size='340' side='right'caption='[[3nfr]], [[Resolution|resolution]] 1.57Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3nfr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EWQ:6,8-DIMETHOXY-1,4-DIMETHYLQUINOLIN-2(1H)-ONE'>EWQ</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[3nfr]] is a 2 chain structure | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfr OCA], [https://pdbe.org/3nfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfr RCSB], [https://www.ebi.ac.uk/pdbsum/3nfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfr ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Quinone reductase|Quinone reductase]] | + | *[[Quinone reductase 3D structures|Quinone reductase 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Cushman | + | [[Category: Large Structures]] |
| - | [[Category: Jermihov | + | [[Category: Cushman M]] |
| - | [[Category: Maiti | + | [[Category: Jermihov K]] |
| - | [[Category: Mesecar | + | [[Category: Maiti A]] |
| - | [[Category: Sturdy | + | [[Category: Mesecar AD]] |
| - | + | [[Category: Sturdy M]] | |
| - | + | ||
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Current revision
Casimiroin analog inhibitor of quinone reductase 2
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