3emn

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[[Image:3emn.png|left|200px]]
 
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{{STRUCTURE_3emn| PDB=3emn | SCENE= }}
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==The Crystal Structure of Mouse VDAC1 at 2.3 A resolution==
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<StructureSection load='3emn' size='340' side='right'caption='[[3emn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===The Crystal Structure of Mouse VDAC1 at 2.3 A resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3emn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EMN FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18988731}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MC3:1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE'>MC3</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3emn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3emn OCA], [https://pdbe.org/3emn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3emn RCSB], [https://www.ebi.ac.uk/pdbsum/3emn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3emn ProSAT]</span></td></tr>
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[[3emn]] is a 1 chain structure of [[Porin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EMN OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDAC1_MOUSE VDAC1_MOUSE] Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.<ref>PMID:10716730</ref> <ref>PMID:15477379</ref> <ref>PMID:18988731</ref>
==See Also==
==See Also==
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*[[Porin|Porin]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018988731</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Abramson, J.]]
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[[Category: Abramson J]]
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[[Category: Cascio, D.]]
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[[Category: Cascio D]]
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[[Category: Colletier, J P.]]
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[[Category: Colletier J-P]]
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[[Category: Faham, S.]]
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[[Category: Faham S]]
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[[Category: Ping, P.]]
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[[Category: Ping P]]
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[[Category: Toro, L.]]
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[[Category: Toro L]]
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[[Category: Ujwal, R.]]
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[[Category: Ujwal R]]
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[[Category: Zhang, J.]]
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[[Category: Zhang J]]
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[[Category: Apoptosis]]
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[[Category: Beta barrel]]
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[[Category: Channel]]
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[[Category: Eukaryotic membrane protein]]
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[[Category: Ion transport]]
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[[Category: Membrane protein]]
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[[Category: Mitochondrion]]
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[[Category: Outer membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Porin]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Vdac1]]
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Current revision

The Crystal Structure of Mouse VDAC1 at 2.3 A resolution

PDB ID 3emn

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