3hf8
From Proteopedia
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| - | [[Image:3hf8.png|left|200px]] | ||
| - | + | ==Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe== | |
| - | + | <StructureSection load='3hf8' size='340' side='right'caption='[[3hf8]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3hf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HF8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ML0:4-{2-AMINO-6-[(1R)-2,2,2-TRIFLUORO-1-(3-FLUOROBIPHENYL-4-YL)ETHOXY]PYRIMIDIN-4-YL}-L-PHENYLALANINE'>ML0</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hf8 OCA], [https://pdbe.org/3hf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hf8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hf8 ProSAT]</span></td></tr> |
| - | [[3hf8]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TPH1_HUMAN TPH1_HUMAN] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/3hf8_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hf8 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Hydroxylases 3D structures|Hydroxylases 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Hunter | + | [[Category: Hunter MJ]] |
| - | [[Category: Swanson | + | [[Category: Swanson RV]] |
| - | [[Category: Tari | + | [[Category: Tari LW]] |
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Current revision
Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe
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