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1pml

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[[Image:1pml.png|left|200px]]
 
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{{STRUCTURE_1pml| PDB=1pml | SCENE= }}
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==KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES==
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<StructureSection load='1pml' size='340' side='right'caption='[[1pml]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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===KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1pml]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PML FirstGlance]. <br>
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{{ABSTRACT_PUBMED_8069221}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pml OCA], [https://pdbe.org/1pml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pml RCSB], [https://www.ebi.ac.uk/pdbsum/1pml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pml ProSAT]</span></td></tr>
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[[1pml]] is a 3 chain structure of [[Plasminogen]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PML OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
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== Function ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pm/1pml_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pml ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Plasminogen|Plasminogen]]
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*[[Plasminogen 3D structures|Plasminogen 3D structures]]
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*[[Plasminogen activator|Plasminogen activator]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:008069221</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: T-plasminogen activator]]
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[[Category: Large Structures]]
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[[Category: Padmanabhan, K.]]
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[[Category: Padmanabhan K]]
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[[Category: Tulinsky, A.]]
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[[Category: Tulinsky A]]

Current revision

KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES

PDB ID 1pml

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