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2x4f

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[[Image:2x4f.png|left|200px]]
 
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{{STRUCTURE_2x4f| PDB=2x4f | SCENE= }}
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==The Crystal Structure of the human myosin light chain kinase LOC340156.==
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<StructureSection load='2x4f' size='340' side='right'caption='[[2x4f]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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===THE CRYSTAL STRUCTURE OF THE HUMAN MYOSIN LIGHT CHAIN KINASE LOC340156.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2x4f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16X:4-(2-AMINO-4-METHYL-1,3-THIAZOL-5-YL)-N-(3-DIOXAZIRIDIN-3-YLPHENYL)PYRIMIDIN-2-AMINE'>16X</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[2x4f]] is a 2 chain structure of [[Myosin light chain kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4F OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4f OCA], [https://pdbe.org/2x4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4f RCSB], [https://www.ebi.ac.uk/pdbsum/2x4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MYLK4_HUMAN MYLK4_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x4f ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Myosin light chain kinase|Myosin light chain kinase]]
*[[Myosin light chain kinase|Myosin light chain kinase]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bountra C]]
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[[Category: Chaikuad, A.]]
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[[Category: Chaikuad A]]
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[[Category: Cocking, R.]]
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[[Category: Cocking R]]
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[[Category: Daga, N.]]
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[[Category: Daga N]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Elkins, J M.]]
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[[Category: Elkins JM]]
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[[Category: Fedorov, O.]]
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[[Category: Fedorov O]]
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[[Category: Gileadi, O.]]
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[[Category: Gileadi O]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Mahajan, P.]]
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[[Category: Mahajan P]]
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[[Category: Muniz, J R.C.]]
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[[Category: Muniz JRC]]
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[[Category: Rellos, P.]]
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[[Category: Rellos P]]
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[[Category: Shrestha, B.]]
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[[Category: Shrestha B]]
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[[Category: Ugochukwu, E.]]
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[[Category: Ugochukwu E]]
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[[Category: Vondelft, F.]]
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[[Category: Wang J]]
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[[Category: Wang, J.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yue W]]
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[[Category: Yue, W.]]
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[[Category: Von Delft F]]
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[[Category: Breast cancer]]
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[[Category: Kinase]]
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[[Category: Lung]]
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[[Category: Myosin]]
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[[Category: Nucleotide-binding]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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Current revision

The Crystal Structure of the human myosin light chain kinase LOC340156.

PDB ID 2x4f

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