3ls8

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[[Image:3ls8.png|left|200px]]
 
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{{STRUCTURE_3ls8| PDB=3ls8 | SCENE= }}
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==Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol==
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<StructureSection load='3ls8' size='340' side='right'caption='[[3ls8]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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===Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ls8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LS8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJZ:3-(4-MORPHOLIN-4-YLTHIENO[3,2-D]PYRIMIDIN-2-YL)PHENOL'>AJZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[3ls8]] is a 2 chain structure of [[Phosphoinositide 3-Kinases]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LS8 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ls8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ls8 OCA], [https://pdbe.org/3ls8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ls8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ls8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ls8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ls/3ls8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ls8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphoinositide 3-Kinases|Phosphoinositide 3-Kinases]]
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
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*[[Phsphatidylinositol 3-kinase|Phsphatidylinositol 3-kinase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphatidylinositol 3-kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berg, S Van den.]]
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[[Category: Berglund H]]
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[[Category: Berglund, H.]]
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[[Category: Bountra C]]
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[[Category: Bountra, C.]]
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[[Category: Collins R]]
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[[Category: Collins, R.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Flodin S]]
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[[Category: Flodin, S.]]
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[[Category: Flores A]]
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[[Category: Flores, A.]]
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[[Category: Graslund S]]
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[[Category: Graslund, S.]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Johansson I]]
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[[Category: Johansson, I.]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T.]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T.]]
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[[Category: Kraulis P]]
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[[Category: Kraulis, P.]]
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[[Category: Moche M]]
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[[Category: Moche, M.]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman T]]
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[[Category: Nyman, T.]]
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[[Category: Persson C]]
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[[Category: Persson, C.]]
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[[Category: Schuler H]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schutz P]]
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[[Category: Schuler, H.]]
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[[Category: Siponen MI]]
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[[Category: Schutz, P.]]
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[[Category: Thorsell AG]]
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[[Category: Siponen, M I.]]
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[[Category: Tresaugues L]]
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[[Category: Thorsell, A G.]]
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[[Category: Van den Berg S]]
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[[Category: Tresaugues, L.]]
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[[Category: Wahlberg E]]
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[[Category: Wahlberg, E.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Welin M]]
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[[Category: Welin, M.]]
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[[Category: Wisniewska M]]
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[[Category: Wisniewska, M.]]
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[[Category: Alpha/beta protein]]
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[[Category: Atp-binding]]
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[[Category: Compound 15e]]
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[[Category: Inhibitor]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphatidylinositol]]
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[[Category: Phosphatidylinositol 3-kinase catalytic subunit type 3]]
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[[Category: Phosphoprotein]]
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[[Category: Pik3c3]]
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[[Category: Sgc]]
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[[Category: Sgc stockholm]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol

PDB ID 3ls8

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OCA

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