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3i8v

From Proteopedia

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[[Image:3i8v.png|left|200px]]
 
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{{STRUCTURE_3i8v| PDB=3i8v | SCENE= }}
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==Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone==
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<StructureSection load='3i8v' size='340' side='right'caption='[[3i8v]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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===Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3i8v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I8V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0MO:(4R)-4-(3-BUTOXY-4-METHOXYBENZYL)IMIDAZOLIDIN-2-ONE'>0MO</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[3i8v]] is a 2 chain structure of [[Phosphodiesterase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8V OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i8v OCA], [https://pdbe.org/3i8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i8v RCSB], [https://www.ebi.ac.uk/pdbsum/3i8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i8v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE4A_HUMAN PDE4A_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:11566027</ref> <ref>PMID:17727341</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/3i8v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i8v ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barker, J.]]
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[[Category: Large Structures]]
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[[Category: Cheng, R K.Y.]]
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[[Category: Barker J]]
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[[Category: Crawley, L.]]
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[[Category: Cheng RKY]]
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[[Category: Felicetti, B.]]
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[[Category: Crawley L]]
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[[Category: Whittaker, M.]]
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[[Category: Felicetti B]]
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[[Category: Wood, M.]]
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[[Category: Whittaker M]]
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[[Category: Camp]]
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[[Category: Wood M]]
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[[Category: Cyclic-amp specific]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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Current revision

Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone

PDB ID 3i8v

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