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1de3
From Proteopedia
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| - | [[Image:1de3.png|left|200px]] | ||
| - | + | ==SOLUTION STRUCTURE OF THE CYTOTOXIC RIBONUCLEASE ALPHA-SARCIN== | |
| - | + | <StructureSection load='1de3' size='340' side='right'caption='[[1de3]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1de3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_giganteus Aspergillus giganteus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DE3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1de3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1de3 OCA], [https://pdbe.org/1de3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1de3 RCSB], [https://www.ebi.ac.uk/pdbsum/1de3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1de3 ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1de3]] is a 1 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/RNAS_ASPGI RNAS_ASPGI] Alpha-sarcin is specific for purines in both single- and double-stranded RNA. Its toxic action on eukaryotic cells is the result of cleavage of a single phosphodiester bond in the 60S subunit of ribosomes. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/1de3_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1de3 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Ribonuclease|Ribonuclease]] | + | *[[Ribonuclease 3D structures|Ribonuclease 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Aspergillus giganteus]] | [[Category: Aspergillus giganteus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Bruix | + | [[Category: Bruix M]] |
| - | [[Category: Campos-Olivas | + | [[Category: Campos-Olivas R]] |
| - | [[Category: Gavilanes | + | [[Category: Gavilanes JG]] |
| - | [[Category: Lacadena | + | [[Category: Lacadena J]] |
| - | [[Category: | + | [[Category: Martinez del Pozo A]] |
| - | [[Category: | + | [[Category: Perez-Canadillas JM]] |
| - | [[Category: Rico | + | [[Category: Rico M]] |
| - | [[Category: Santoro | + | [[Category: Santoro J]] |
| - | + | ||
| - | + | ||
Current revision
SOLUTION STRUCTURE OF THE CYTOTOXIC RIBONUCLEASE ALPHA-SARCIN
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