3ljb

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[[Image:3ljb.png|left|200px]]
 
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{{STRUCTURE_3ljb| PDB=3ljb | SCENE= }}
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==Structural basis of oligomerisation in the MxA stalk==
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<StructureSection load='3ljb' size='340' side='right'caption='[[3ljb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Structural basis of oligomerisation in the MxA stalk===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ljb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LJB FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20428112}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ljb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ljb OCA], [https://pdbe.org/3ljb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ljb RCSB], [https://www.ebi.ac.uk/pdbsum/3ljb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ljb ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3ljb]] is a 2 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LJB OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/MX1_HUMAN MX1_HUMAN] Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.<ref>PMID:20603636</ref> <ref>PMID:11880649</ref> <ref>PMID:15047845</ref> <ref>PMID:14752052</ref> <ref>PMID:15355513</ref> <ref>PMID:14687945</ref> <ref>PMID:15757897</ref> <ref>PMID:16413306</ref> <ref>PMID:16202617</ref> <ref>PMID:17374778</ref> <ref>PMID:18668195</ref> <ref>PMID:19109387</ref> <ref>PMID:21900240</ref> <ref>PMID:21992152</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lj/3ljb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ljb ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[GTP-binding protein|GTP-binding protein]]
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020428112</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Daumke, O.]]
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[[Category: Large Structures]]
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[[Category: Gao, S.]]
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[[Category: Daumke O]]
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[[Category: Antiviral protein]]
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[[Category: Gao S]]
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[[Category: Four-helix-bundle]]
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[[Category: Gtp-binding]]
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Current revision

Structural basis of oligomerisation in the MxA stalk

PDB ID 3ljb

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