2csb

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[[Image:2csb.png|left|200px]]
 
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{{STRUCTURE_2csb| PDB=2csb | SCENE= }}
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==Crystal structure of Topoisomerase V from Methanopyrus kandleri (61 kDa fragment)==
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<StructureSection load='2csb' size='340' side='right'caption='[[2csb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2csb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanopyrus_kandleri Methanopyrus kandleri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2csb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2csb OCA], [https://pdbe.org/2csb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2csb RCSB], [https://www.ebi.ac.uk/pdbsum/2csb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2csb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q977W1_9EURY Q977W1_9EURY]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Topoisomerases are involved in controlling and maintaining the topology of DNA and are present in all kingdoms of life. Unlike all other types of topoisomerases, similar type IB enzymes have only been identified in bacteria and eukarya. The only putative type IB topoisomerase in archaea is represented by Methanopyrus kandleri topoisomerase V. Despite several common functional characteristics, topoisomerase V shows no sequence similarity to other members of the same type. The structure of the 61 kDa N-terminal fragment of topoisomerase V reveals no structural similarity to other topoisomerases. Furthermore, the structure of the active site region is different, suggesting no conservation in the cleavage and religation mechanism. Additionally, the active site is buried, indicating the need of a conformational change for activity. The presence of a topoisomerase in archaea with a unique structure suggests the evolution of a separate mechanism to alter DNA.
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===Crystal structure of Topoisomerase V from Methanopyrus kandleri (61 kDa fragment)===
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Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases.,Taneja B, Patel A, Slesarev A, Mondragon A EMBO J. 2006 Jan 25;25(2):398-408. Epub 2006 Jan 5. PMID:16395333<ref>PMID:16395333</ref>
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{{ABSTRACT_PUBMED_16395333}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2csb" style="background-color:#fffaf0;"></div>
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[[2csb]] is a 2 chain structure of [[Topoisomerase]] with sequence from [http://en.wikipedia.org/wiki/Methanopyrus_kandleri Methanopyrus kandleri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSB OCA].
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==See Also==
==See Also==
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*[[Topoisomerase|Topoisomerase]]
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016395333</ref><references group="xtra"/>
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__TOC__
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[[Category: Methanopyrus kandleri]]
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</StructureSection>
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[[Category: Mondragon, A.]]
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[[Category: Large Structures]]
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[[Category: Patel, A.]]
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[[Category: Slesarev, A.]]
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[[Category: Taneja, B.]]
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[[Category: Helix-hairpin-helix]]
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[[Category: Helix-turn-helix]]
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[[Category: Hhh motif]]
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[[Category: Isomerase]]
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[[Category: Methanopyrus kandleri]]
[[Category: Methanopyrus kandleri]]
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[[Category: Three helix bundle]]
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[[Category: Mondragon A]]
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[[Category: Topoisomerase ib]]
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[[Category: Patel A]]
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[[Category: Topoisomerase v]]
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[[Category: Slesarev A]]
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[[Category: Taneja B]]

Current revision

Crystal structure of Topoisomerase V from Methanopyrus kandleri (61 kDa fragment)

PDB ID 2csb

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