1jaq

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[[Image:1jaq.png|left|200px]]
 
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{{STRUCTURE_1jaq| PDB=1jaq | SCENE= }}
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==COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)==
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<StructureSection load='1jaq' size='340' side='right'caption='[[1jaq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jaq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JAQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_7737183}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=01S:N-[(2R)-2-(HYDROXYCARBAMOYL)-4-METHYLPENTANOYL]-L-ALANYLGLYCINAMIDE'>01S</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jaq OCA], [https://pdbe.org/1jaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jaq RCSB], [https://www.ebi.ac.uk/pdbsum/1jaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jaq ProSAT]</span></td></tr>
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[[1jaq]] is a 1 chain structure of [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAQ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/1jaq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jaq ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:007737183</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Neutrophil collagenase]]
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[[Category: Large Structures]]
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[[Category: Bode, W.]]
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[[Category: Bode W]]
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[[Category: Grams, F.]]
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[[Category: Grams F]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Kleine, T.]]
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[[Category: Kleine T]]
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[[Category: Piper, M.]]
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[[Category: Piper M]]
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[[Category: Powers, J C.]]
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[[Category: Powers JC]]
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[[Category: Reinemer, P.]]
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[[Category: Reinemer P]]
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[[Category: Tschesche, H.]]
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[[Category: Tschesche H]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Metalloprotease]]
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[[Category: Metzincin]]
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[[Category: Zinc-endopeptidase]]
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Current revision

COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)

PDB ID 1jaq

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