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1jii

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[[Image:1jii.png|left|200px]]
 
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{{STRUCTURE_1jii| PDB=1jii | SCENE= }}
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==Crystal structure of S. aureus TyrRS in complex with SB-219383==
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<StructureSection load='1jii' size='340' side='right'caption='[[1jii]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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===Crystal structure of S. aureus TyrRS in complex with SB-219383===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jii]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JII FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11567092}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=383:[2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]-+(2,4,5,8-TETRAHYDROXY-7-OXA-2-AZA-BICYCLO[3.2.1]OCT-3-YL)-+ACETIC+ACID'>383</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jii OCA], [https://pdbe.org/1jii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jii RCSB], [https://www.ebi.ac.uk/pdbsum/1jii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jii ProSAT]</span></td></tr>
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[[1jii]] is a 1 chain structure of [[Aminoacyl tRNA Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JII OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYY_STAAE SYY_STAAE] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).[HAMAP-Rule:MF_02006]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/1jii_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jii ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011567092</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: Staphylococcus aureus]]
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Janson, C A.]]
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[[Category: Jarvest, R L.]]
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[[Category: Qiu, X.]]
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[[Category: Smith, W W.]]
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[[Category: Ligase]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Structure based inhibitor design]]
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[[Category: Janson CA]]
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[[Category: Truncation]]
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[[Category: Jarvest RL]]
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[[Category: Tyrosyl-trna synthetase]]
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[[Category: Qiu X]]
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[[Category: Smith WW]]

Current revision

Crystal structure of S. aureus TyrRS in complex with SB-219383

PDB ID 1jii

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