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1fyv

From Proteopedia

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[[Image:1fyv.png|left|200px]]
 
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{{STRUCTURE_1fyv| PDB=1fyv | SCENE= }}
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==CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1==
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<StructureSection load='1fyv' size='340' side='right'caption='[[1fyv]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1fyv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYV FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11081518}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyv OCA], [https://pdbe.org/1fyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyv RCSB], [https://www.ebi.ac.uk/pdbsum/1fyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyv ProSAT]</span></td></tr>
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[[1fyv]] is a 1 chain structure of [[Toll-like Receptors]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYV OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLR1_HUMAN TLR1_HUMAN] Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/1fyv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fyv ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Toll-like Receptors|Toll-like Receptors]]
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:011081518</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Horng, T.]]
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[[Category: Large Structures]]
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[[Category: Manley, J L.]]
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[[Category: Horng T]]
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[[Category: Medzhitov, R.]]
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[[Category: Manley JL]]
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[[Category: Shen, B.]]
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[[Category: Medzhitov R]]
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[[Category: Tao, X.]]
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[[Category: Shen B]]
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[[Category: Tong, L.]]
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[[Category: Tao X]]
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[[Category: Xu, Y.]]
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[[Category: Tong L]]
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[[Category: Beta-alpha-beta fold parallel beta sheet]]
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[[Category: Xu Y]]
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[[Category: Signaling protein]]
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Current revision

CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1

PDB ID 1fyv

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