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1ms6
From Proteopedia
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| - | [[Image:1ms6.png|left|200px]] | ||
| - | + | ==Dipeptide Nitrile Inhibitor Bound to Cathepsin S.== | |
| - | + | <StructureSection load='1ms6' size='340' side='right'caption='[[1ms6]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1ms6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MS6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLN:MORPHOLINE-4-CARBOXYLIC+ACID+[1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE'>BLN</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms6 OCA], [https://pdbe.org/1ms6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ms6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ms6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms6 ProSAT]</span></td></tr> |
| - | [[1ms6]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms6_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ms6 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Cathepsin|Cathepsin]] | + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | + | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bekkali | + | [[Category: Large Structures]] |
| - | [[Category: Brown | + | [[Category: Bekkali Y]] |
| - | [[Category: Crane | + | [[Category: Brown ML]] |
| - | [[Category: Cywin | + | [[Category: Crane K]] |
| - | [[Category: Davidson | + | [[Category: Cywin CL]] |
| - | [[Category: DeTuri | + | [[Category: Davidson W]] |
| - | [[Category: Emmanuel | + | [[Category: DeTuri M]] |
| - | [[Category: Freeman | + | [[Category: Emmanuel MJ]] |
| - | [[Category: Frye | + | [[Category: Freeman DM]] |
| - | [[Category: Giradot | + | [[Category: Frye LL]] |
| - | [[Category: Grygon | + | [[Category: Giradot M]] |
| - | [[Category: Hao | + | [[Category: Grygon CA]] |
| - | [[Category: Hopkins | + | [[Category: Hao MH]] |
| - | [[Category: Hrapchak | + | [[Category: Hopkins JL]] |
| - | [[Category: Labadia | + | [[Category: Hrapchak M]] |
| - | [[Category: McNeil | + | [[Category: Labadia ME]] |
| - | [[Category: Morwick | + | [[Category: McNeil D]] |
| - | [[Category: Pav | + | [[Category: Morwick T]] |
| - | [[Category: Spero | + | [[Category: Pav S]] |
| - | [[Category: Thomson | + | [[Category: Spero DM]] |
| - | [[Category: Wang | + | [[Category: Thomson DS]] |
| - | [[Category: Ward | + | [[Category: Wang Y]] |
| - | [[Category: White | + | [[Category: Ward YD]] |
| - | [[Category: Zindell | + | [[Category: White D]] |
| - | + | [[Category: Zindell R]] | |
| - | + | ||
| - | + | ||
Current revision
Dipeptide Nitrile Inhibitor Bound to Cathepsin S.
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Categories: Homo sapiens | Large Structures | Bekkali Y | Brown ML | Crane K | Cywin CL | Davidson W | DeTuri M | Emmanuel MJ | Freeman DM | Frye LL | Giradot M | Grygon CA | Hao MH | Hopkins JL | Hrapchak M | Labadia ME | McNeil D | Morwick T | Pav S | Spero DM | Thomson DS | Wang Y | Ward YD | White D | Zindell R
