966c

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[[Image:966c.png|left|200px]]
 
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{{STRUCTURE_966c| PDB=966c | SCENE= }}
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==CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID==
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<StructureSection load='966c' size='340' side='right'caption='[[966c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[966c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=966C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=966C FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10074939}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=RS2:N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE'>RS2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=966c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=966c OCA], [https://pdbe.org/966c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=966c RCSB], [https://www.ebi.ac.uk/pdbsum/966c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=966c ProSAT]</span></td></tr>
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[[966c]] is a 1 chain structure of [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=966C OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP1_HUMAN MMP1_HUMAN] Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.<ref>PMID:1645757</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/66/966c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=966c ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010074939</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Broka, C.]]
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[[Category: Large Structures]]
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[[Category: Browner, M F.]]
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[[Category: Broka C]]
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[[Category: Campbell, J.]]
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[[Category: Browner MF]]
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[[Category: Carr, S.]]
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[[Category: Campbell J]]
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[[Category: Hendricks, R T.]]
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[[Category: Carr S]]
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[[Category: Lovejoy, B.]]
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[[Category: Hendricks RT]]
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[[Category: Luong, C.]]
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[[Category: Lovejoy B]]
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[[Category: Martin, R.]]
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[[Category: Luong C]]
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[[Category: Walker, K.]]
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[[Category: Martin R]]
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[[Category: Wart, H Van.]]
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[[Category: Van Wart H]]
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[[Category: Welch, A.]]
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[[Category: Walker K]]
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[[Category: Matrix metalloprotease]]
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[[Category: Welch A]]

Current revision

CRYSTAL STRUCTURE OF FIBROBLAST COLLAGENASE-1 COMPLEXED TO A DIPHENYL-ETHER SULPHONE BASED HYDROXAMIC ACID

PDB ID 966c

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OCA

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