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1f4c

From Proteopedia

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[[Image:1f4c.png|left|200px]]
 
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{{STRUCTURE_1f4c| PDB=1f4c | SCENE= }}
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==CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COVALENTLY MODIFIED AT C146 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL==
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<StructureSection load='1f4c' size='340' side='right'caption='[[1f4c]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COVALENTLY MODIFIED AT C146 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1f4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F4C FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10944209}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TP2:N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL'>TP2</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f4c OCA], [https://pdbe.org/1f4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f4c RCSB], [https://www.ebi.ac.uk/pdbsum/1f4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f4c ProSAT]</span></td></tr>
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[[1f4c]] is a 2 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F4C OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f4/1f4c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f4c ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thymidylate synthase|Thymidylate synthase]]
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010944209</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Thymidylate synthase]]
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[[Category: Large Structures]]
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[[Category: Braisted, A C.]]
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[[Category: Braisted AC]]
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[[Category: Erlanson, D A.]]
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[[Category: Erlanson DA]]
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[[Category: Gordon, E.]]
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[[Category: Gordon E]]
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[[Category: Randal, M.]]
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[[Category: Randal M]]
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[[Category: Raphael, D R.]]
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[[Category: Raphael DR]]
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[[Category: Stroud, R M.]]
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[[Category: Stroud RM]]
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[[Category: Wells, J A.]]
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[[Category: Wells JA]]
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[[Category: E. coli thymidylate synthase modified at cysteine 146]]
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[[Category: Transferase]]
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Current revision

CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE COVALENTLY MODIFIED AT C146 WITH N-[TOSYL-D-PROLINYL]AMINO-ETHANETHIOL

PDB ID 1f4c

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