This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ycr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:56, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ycr.png|left|200px]]
 
-
{{STRUCTURE_1ycr| PDB=1ycr | SCENE= }}
+
==MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53==
-
 
+
<StructureSection load='1ycr' size='340' side='right'caption='[[1ycr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
===MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1ycr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YCR FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_8875929}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ycr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ycr OCA], [https://pdbe.org/1ycr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ycr RCSB], [https://www.ebi.ac.uk/pdbsum/1ycr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ycr ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1ycr]] is a 2 chain structure of [[MDM2]] and [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YCR OCA].
+
== Disease ==
 +
[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yc/1ycr_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ycr ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[MDM2|MDM2]]
+
*[[MDM2 3D structures|MDM2 3D structures]]
-
*[[P53|P53]]
+
*[[P53 3D structures|P53 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:008875929</ref><ref group="xtra">PMID:014695246</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Kussie, P H.]]
+
[[Category: Large Structures]]
-
[[Category: Pavletich, N P.]]
+
[[Category: Kussie PH]]
-
[[Category: Activator]]
+
[[Category: Pavletich NP]]
-
[[Category: Anti-oncogene]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Nuclear protein]]
+
-
[[Category: Phosphorylation]]
+
-
[[Category: Transcription regulation]]
+

Current revision

MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53

PDB ID 1ycr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ycr"
Personal tools