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3der

From Proteopedia

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[[Image:3der.png|left|200px]]
 
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{{STRUCTURE_3der| PDB=3der | SCENE= }}
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==Crystal structure of dipeptide epimerase from Thermotoga maritima complexed with L-Ala-L-Lys dipeptide==
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<StructureSection load='3der' size='340' side='right'caption='[[3der]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal structure of dipeptide epimerase from Thermotoga maritima complexed with L-Ala-L-Lys dipeptide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3der]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DER FirstGlance]. <br>
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{{ABSTRACT_PUBMED_19000819}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3der FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3der OCA], [https://pdbe.org/3der PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3der RCSB], [https://www.ebi.ac.uk/pdbsum/3der PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3der ProSAT]</span></td></tr>
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[[3der]] is a 4 chain structure of [[Muconate cycloisomerase]] with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DER OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AEEP_THEMA AEEP_THEMA] Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has probably a role in the metabolism of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of a broad range of other dipeptides; is most efficient with L-Ala-D/L-Phe, L-Ala-D/L-Tyr, and L-Ala-D/L-His.<ref>PMID:19000819</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/3der_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3der ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Muconate cycloisomerase|Muconate cycloisomerase]]
*[[Muconate cycloisomerase|Muconate cycloisomerase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019000819</ref><references group="xtra"/>
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__TOC__
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[[Category: Thermotoga maritima msb8]]
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</StructureSection>
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[[Category: Almo, S C.]]
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[[Category: Large Structures]]
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[[Category: Fedorov, A A.]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Fedorov, E V.]]
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[[Category: Almo SC]]
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[[Category: Gerlt, J A.]]
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[[Category: Fedorov AA]]
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[[Category: Imker, H J.]]
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[[Category: Fedorov EV]]
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[[Category: Dipeptide epimerase]]
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[[Category: Gerlt JA]]
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[[Category: Enzymatic function]]
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[[Category: Imker HJ]]
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[[Category: Isomerase]]
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[[Category: Thermotoga maritima]]
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Current revision

Crystal structure of dipeptide epimerase from Thermotoga maritima complexed with L-Ala-L-Lys dipeptide

PDB ID 3der

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