1zbq

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[[Image:1zbq.png|left|200px]]
 
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{{STRUCTURE_1zbq| PDB=1zbq | SCENE= }}
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==Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD==
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<StructureSection load='1zbq' size='340' side='right'caption='[[1zbq]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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===Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zbq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZBQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_016574148}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zbq OCA], [https://pdbe.org/1zbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zbq RCSB], [https://www.ebi.ac.uk/pdbsum/1zbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zbq ProSAT]</span></td></tr>
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[[1zbq]] is a 6 chain structure of [[Alcohol dehydrogenase]] and [[Hydroxysteroid dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZBQ OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN] Defects in HSD17B4 are a cause of D-bifunctional protein deficiency (DBPD) [MIM:[https://omim.org/entry/261515 261515]. DBPD is a disorder of peroxisomal fatty acid beta-oxidation.<ref>PMID:9482850</ref> <ref>PMID:10400999</ref> <ref>PMID:11743515</ref> Defects in HSD17B4 are the cause of Perrault syndrome (PRLTS1) [MIM:[https://omim.org/entry/233400 233400]. A sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement.<ref>PMID:20673864</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DHB4_HUMAN DHB4_HUMAN] Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.<ref>PMID:9089413</ref> <ref>PMID:8902629</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zb/1zbq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zbq ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Alcohol dehydrogenase|Alcohol dehydrogenase]]
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*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
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*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016574148</ref><references group="xtra"/>
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__TOC__
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[[Category: 3-hydroxyacyl-CoA dehydrogenase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bray, J.]]
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[[Category: Arrowsmith C]]
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[[Category: Delft, F Von.]]
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[[Category: Bray J]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Kavanagh, K.]]
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[[Category: Kavanagh K]]
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[[Category: Lukacik, P.]]
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[[Category: Lukacik P]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Shafqat N]]
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[[Category: Shafqat, N.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Von Delft F]]
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[[Category: Human]]
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[[Category: Hydroxysteroid dehydrogenase]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxisomal beta-oxidation]]
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[[Category: Sgc]]
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[[Category: Short-chain dehydrogenase]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD

PDB ID 1zbq

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