3pkc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:41, 21 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3pkc.png|left|200px]]
 
-
{{STRUCTURE_3pkc| PDB=3pkc | SCENE= }}
+
==M. tuberculosis MetAP with bengamide analog Y08, in Mn form==
-
 
+
<StructureSection load='3pkc' size='340' side='right'caption='[[3pkc]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
-
===M. tuberculosis MetAP with bengamide analog Y08, in Mn form===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[3pkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKC FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_21465667}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=Y08:(E,2R,3R,4S,5R)-N-[[(3S)-1-CYCLOPROPYLCARBONYLPIPERIDIN-3-YL]METHYL]-2-METHOXY-8,8-DIMETHYL-3,4,5-TRIS(OXIDANYL)NON-6-ENAMIDE'>Y08</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkc OCA], [https://pdbe.org/3pkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pkc RCSB], [https://www.ebi.ac.uk/pdbsum/3pkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pkc ProSAT]</span></td></tr>
-
[[3pkc]] is a 1 chain structure of [[Aminopeptidase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKC OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MAP12_MYCTU MAP12_MYCTU] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:19688379</ref> <ref>PMID:20038112</ref>
==See Also==
==See Also==
-
*[[Aminopeptidase|Aminopeptidase]]
+
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:021465667</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Methionyl aminopeptidase]]
+
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
-
[[Category: Lu, J P.]]
+
[[Category: Lu JP]]
-
[[Category: Ye, Q Z.]]
+
[[Category: Ye QZ]]
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+

Current revision

M. tuberculosis MetAP with bengamide analog Y08, in Mn form

PDB ID 3pkc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3pkc"
Personal tools