3cce

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[[Image:3cce.png|left|200px]]
 
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{{STRUCTURE_3cce| PDB=3cce | SCENE= }}
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==Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A==
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<StructureSection load='3cce' size='340' side='right'caption='[[3cce]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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===Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3cce]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CCE FirstGlance]. <br>
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{{ABSTRACT_PUBMED_18455733}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cce OCA], [https://pdbe.org/3cce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cce RCSB], [https://www.ebi.ac.uk/pdbsum/3cce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cce ProSAT]</span></td></tr>
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[[3cce]] is a 30 chain structure of [[Ribosomal protein L10]], [[Ribosomal protein L11]], [[Ribosomal protein L13]], [[Ribosomal protein L14]], [[Ribosomal protein L19]], [[Ribosomal protein L2]], [[Ribosomal protein L21]], [[Ribosomal protein L3]], [[Ribosomal protein L34]], [[Ribosomal protein L4]], [[Ribosomal protein L5]], [[Ribosomal protein L6]], [[Ribosomal protein L7]] and [[Ribosome]] with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CCE OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL2_HALMA RL2_HALMA] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_A]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3cce_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cce ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ribosomal protein L10|Ribosomal protein L10]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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*[[Ribosomal protein L11|Ribosomal protein L11]]
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__TOC__
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*[[Ribosomal protein L13|Ribosomal protein L13]]
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</StructureSection>
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*[[Ribosomal protein L14|Ribosomal protein L14]]
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*[[Ribosomal protein L19|Ribosomal protein L19]]
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*[[Ribosomal protein L2|Ribosomal protein L2]]
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*[[Ribosomal protein L21|Ribosomal protein L21]]
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*[[Ribosomal protein L3|Ribosomal protein L3]]
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*[[Ribosomal protein L34|Ribosomal protein L34]]
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*[[Ribosomal protein L4|Ribosomal protein L4]]
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*[[Ribosomal protein L5|Ribosomal protein L5]]
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*[[Ribosomal protein L6|Ribosomal protein L6]]
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*[[Ribosomal protein L7|Ribosomal protein L7]]
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*[[Ribosome|Ribosome]]
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==Reference==
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<ref group="xtra">PMID:018455733</ref><references group="xtra"/>
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[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
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[[Category: Blaha, G.]]
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[[Category: Large Structures]]
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[[Category: Gurel, G.]]
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[[Category: Blaha G]]
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[[Category: 23s rrna mutation u2535a]]
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[[Category: Gurel G]]
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[[Category: Ribosome]]
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Current revision

Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A

PDB ID 3cce

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