2arw
From Proteopedia
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| - | [[Image:2arw.png|left|200px]] | ||
| - | + | ==The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor== | |
| - | + | <StructureSection load='2arw' size='340' side='right'caption='[[2arw]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ARW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2arw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arw OCA], [https://pdbe.org/2arw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2arw RCSB], [https://www.ebi.ac.uk/pdbsum/2arw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2arw ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[2arw]] is a 1 chain structure | + | == Function == |
| + | [https://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref> Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2arw_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2arw ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Interleukin receptor|Interleukin receptor]] | + | *[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Dingley | + | [[Category: Large Structures]] |
| - | [[Category: Grotzinger | + | [[Category: Dingley AJ]] |
| - | [[Category: Hecht | + | [[Category: Grotzinger J]] |
| - | [[Category: Ozbek | + | [[Category: Hecht O]] |
| - | [[Category: Rose-John | + | [[Category: Ozbek S]] |
| - | [[Category: Schwantner | + | [[Category: Rose-John S]] |
| - | + | [[Category: Schwantner A]] | |
| - | + | ||
Current revision
The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor
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