1mug

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1mug" [edit=sysop:move=sysop])
Current revision (07:48, 14 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1mug.png|left|200px]]
 
-
{{STRUCTURE_1mug| PDB=1mug | SCENE= }}
+
==G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI==
-
 
+
<StructureSection load='1mug' size='340' side='right'caption='[[1mug]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
===G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1mug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MUG FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_9489705}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mug OCA], [https://pdbe.org/1mug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mug RCSB], [https://www.ebi.ac.uk/pdbsum/1mug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mug ProSAT]</span></td></tr>
-
[[1mug]] is a 1 chain structure of [[DNA glycosylate]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUG OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MUG_ECOLI MUG_ECOLI] Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.<ref>PMID:8878487</ref> <ref>PMID:12668677</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mu/1mug_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mug ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[DNA glycosylate|DNA glycosylate]]
+
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:009489705</ref><ref group="xtra">PMID:009699633</ref><ref group="xtra">PMID:011742118</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Barlow, T.]]
+
[[Category: Large Structures]]
-
[[Category: Barrett, T E.]]
+
[[Category: Barlow T]]
-
[[Category: Brown, T.]]
+
[[Category: Barrett TE]]
-
[[Category: Jiricny, J.]]
+
[[Category: Brown T]]
-
[[Category: Panayotou, G.]]
+
[[Category: Jiricny J]]
-
[[Category: Pearl, L H.]]
+
[[Category: Panayotou G]]
-
[[Category: Savva, R.]]
+
[[Category: Pearl LH]]
-
[[Category: Dna-glycosylase]]
+
[[Category: Savva R]]
-
[[Category: Hydrolase]]
+

Current revision

G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI

PDB ID 1mug

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mug"
Personal tools