3ks9

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[[Image:3ks9.png|left|200px]]
 
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{{STRUCTURE_3ks9| PDB=3ks9 | SCENE= }}
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==Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist==
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<StructureSection load='3ks9' size='340' side='right'caption='[[3ks9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ks9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KS9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
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[[3ks9]] is a 2 chain structure of [[Ionotropic Glutamate Receptors]] and [[Metabotropic glutamate receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KS9 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ks9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ks9 OCA], [https://pdbe.org/3ks9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ks9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ks9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ks9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22901947</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.<ref>PMID:7476890</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/3ks9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ks9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]]
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*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]]
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*[[Metabotropic glutamate receptor|Metabotropic glutamate receptor]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C.]]
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[[Category: Bochkarev A]]
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[[Category: Cossar, D.]]
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[[Category: Bountra C]]
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[[Category: Dobrovetsky, E.]]
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[[Category: Cossar D]]
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[[Category: Edwards, A M.]]
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[[Category: Dobrovetsky E]]
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[[Category: Khutoreskaya, G.]]
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[[Category: Edwards AM]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Khutoreskaya G]]
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[[Category: Seitova, A.]]
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[[Category: Seitova A]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Cell membrane]]
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[[Category: Dimerization]]
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[[Category: G-protein coupled receptor]]
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[[Category: Glutamate receptor]]
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[[Category: Glutamic acid binding]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Mglur1]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transducer]]
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[[Category: Transmembrane]]
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Current revision

Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist

PDB ID 3ks9

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