2r4h

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[[Image:2r4h.png|left|200px]]
 
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{{STRUCTURE_2r4h| PDB=2r4h | SCENE= }}
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==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase==
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<StructureSection load='2r4h' size='340' side='right'caption='[[2r4h]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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===Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>
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[[2r4h]] is a 3 chain structure of [[Guanylate kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [https://pdbe.org/2r4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [https://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Guanylate kinase|Guanylate kinase]]
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*[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Cooper, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F von.]]
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[[Category: Cooper C]]
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[[Category: Doyle, D A.]]
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[[Category: Doyle DA]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Elkins, J M.]]
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[[Category: Elkins JM]]
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[[Category: Hozjan, V.]]
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[[Category: Hozjan V]]
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[[Category: Kavanagh, K L.]]
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[[Category: Kavanagh KL]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: Pilka, E S.]]
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[[Category: Pilka ES]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Atp-binding]]
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[[Category: Cell junction]]
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[[Category: Membrane associated guanylate kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Pdz]]
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[[Category: Phosphorylation]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Tight junction]]
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[[Category: Transferase]]
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Current revision

Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase

PDB ID 2r4h

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