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1zkj

From Proteopedia

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[[Image:1zkj.png|left|200px]]
 
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{{STRUCTURE_1zkj| PDB=1zkj | SCENE= }}
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==Structural Basis for the Extended Substrate Spectrum of CMY-10, a Plasmid-Encoded Class C beta-lactamase==
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<StructureSection load='1zkj' size='340' side='right'caption='[[1zkj]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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===Structural Basis for the Extended Substrate Spectrum of CMY-10, a Plasmid-Encoded Class C beta-lactamase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zkj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_aerogenes Klebsiella aerogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZKJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16677302}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkj OCA], [https://pdbe.org/1zkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zkj RCSB], [https://www.ebi.ac.uk/pdbsum/1zkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zkj ProSAT]</span></td></tr>
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[[1zkj]] is a 1 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Enterobacter_aerogenes Enterobacter aerogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKJ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q99QC1_KLEAE Q99QC1_KLEAE] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.[ARBA:ARBA00003808]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zk/1zkj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zkj ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:016677302</ref><references group="xtra"/>
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[[Category: Klebsiella aerogenes]]
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Enterobacter aerogenes]]
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[[Category: An YJ]]
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[[Category: An, Y J.]]
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[[Category: Cha SS]]
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[[Category: Cha, S S.]]
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[[Category: Jung HI]]
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[[Category: Jung, H I.]]
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[[Category: Lee SH]]
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[[Category: Lee, S H.]]
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[[Category: Class c]]
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[[Category: Cmy-10]]
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[[Category: Extended spectrum beta-lactamase]]
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[[Category: Hydrolase]]
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Current revision

Structural Basis for the Extended Substrate Spectrum of CMY-10, a Plasmid-Encoded Class C beta-lactamase

PDB ID 1zkj

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