1m2o

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[[Image:1m2o.png|left|200px]]
 
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{{STRUCTURE_1m2o| PDB=1m2o | SCENE= }}
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==Crystal Structure of the Sec23-Sar1 complex==
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<StructureSection load='1m2o' size='340' side='right'caption='[[1m2o]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal Structure of the Sec23-Sar1 complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m2o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2O FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12239560}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2o OCA], [https://pdbe.org/1m2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2o RCSB], [https://www.ebi.ac.uk/pdbsum/1m2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2o ProSAT]</span></td></tr>
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[[1m2o]] is a 4 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2O OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SEC23_YEAST SEC23_YEAST] Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC23 interacts with BET3 in order to target TRAPPI complex to COPII involved in internalisation of plasma membrane proteins like the maltose transporter.<ref>PMID:2670558</ref> <ref>PMID:6996832</ref> <ref>PMID:7026045</ref> <ref>PMID:3293799</ref> <ref>PMID:3049622</ref> <ref>PMID:2188733</ref> <ref>PMID:1498369</ref> <ref>PMID:7925484</ref> <ref>PMID:8451644</ref> <ref>PMID:8548805</ref> <ref>PMID:8909535</ref> <ref>PMID:9427388</ref> <ref>PMID:9023343</ref> <ref>PMID:9624457</ref> <ref>PMID:9428766</ref> <ref>PMID:10198022</ref> <ref>PMID:11086000</ref> <ref>PMID:10720463</ref> <ref>PMID:12941276</ref> <ref>PMID:14627716</ref> <ref>PMID:16269340</ref> <ref>PMID:17287728</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m2o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m2o ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[GTP-binding protein|GTP-binding protein]]
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012239560</ref><ref group="xtra">PMID:016990852</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Bi, X.]]
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[[Category: Bi X]]
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[[Category: Corpina, R A.]]
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[[Category: Corpina RA]]
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[[Category: Goldberg, J.]]
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[[Category: Goldberg J]]
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[[Category: Beta barrel]]
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[[Category: Gelsolin domain]]
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[[Category: Protein transport-signaling protein complex]]
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[[Category: Vwa domain]]
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[[Category: Zinc-finger]]
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Current revision

Crystal Structure of the Sec23-Sar1 complex

PDB ID 1m2o

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