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4ajj

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[[Image:4ajj.png|left|200px]]
 
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{{STRUCTURE_4ajj| PDB=4ajj | SCENE= }}
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==rat LDHA in complex with 2-((3,4-dimethoxyphenyl)methyl))propanedioic acid and N-(2-methyl-1,3-benzothiazol-6-yl)-3-ureido-propanamide==
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<StructureSection load='4ajj' size='340' side='right'caption='[[4ajj]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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===rat LDHA in complex with 2-((3,4-dimethoxyphenyl)methyl))propanedioic acid and N-(2-methyl-1,3-benzothiazol-6-yl)-3-ureido-propanamide===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ajj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AJJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22417091}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=88R:2-((3,4-DIMETHOXYPHENYL)METHYL))PROPANEDIOIC+ACID'>88R</scene>, <scene name='pdbligand=88S:N-(2-METHYL-1,3-BENZOTHIAZOL-6-YL)-3-UREIDO-PROPANAMIDE'>88S</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ajj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ajj OCA], [https://pdbe.org/4ajj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ajj RCSB], [https://www.ebi.ac.uk/pdbsum/4ajj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ajj ProSAT]</span></td></tr>
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[[4ajj]] is a 4 chain structure of [[Lactate Dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJJ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LDHA_RAT LDHA_RAT]
==See Also==
==See Also==
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*[[Lactate Dehydrogenase|Lactate Dehydrogenase]]
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*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022417091</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: L-lactate dehydrogenase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Brassington, C.]]
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[[Category: Brassington C]]
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[[Category: Davies, G.]]
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[[Category: Davies G]]
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[[Category: Greenwood, R.]]
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[[Category: Greenwood R]]
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[[Category: Hassall, G.]]
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[[Category: Hassall G]]
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[[Category: Patel, J.]]
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[[Category: Patel J]]
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[[Category: Tart, J.]]
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[[Category: Tart J]]
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[[Category: Tucker, J A.]]
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[[Category: Tucker JA]]
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[[Category: Vogtherr, M.]]
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[[Category: Vogtherr M]]
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[[Category: Ward, R.]]
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[[Category: Ward R]]
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[[Category: Fragment based lead generated inhibitor]]
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[[Category: Oxidoreductase-inhibitor complex]]
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Current revision

rat LDHA in complex with 2-((3,4-dimethoxyphenyl)methyl))propanedioic acid and N-(2-methyl-1,3-benzothiazol-6-yl)-3-ureido-propanamide

PDB ID 4ajj

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