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2a1d

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[[Image:2a1d.png|left|200px]]
 
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{{STRUCTURE_2a1d| PDB=2a1d | SCENE= }}
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==Staphylocoagulase bound to bovine thrombin==
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<StructureSection load='2a1d' size='340' side='right'caption='[[2a1d]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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===Staphylocoagulase bound to bovine thrombin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2a1d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A1D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16230338}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0G6:D-PHENYLALANYL-N-[(2S,3S)-6-{[AMINO(IMINIO)METHYL]AMINO}-1-CHLORO-2-HYDROXYHEXAN-3-YL]-L-PROLINAMIDE'>0G6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a1d OCA], [https://pdbe.org/2a1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a1d RCSB], [https://www.ebi.ac.uk/pdbsum/2a1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a1d ProSAT]</span></td></tr>
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[[2a1d]] is a 6 chain structure of [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A1D OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THRB_BOVIN THRB_BOVIN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/2a1d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a1d ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thrombin|Thrombin]]
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*[[Thrombin 3D Structures|Thrombin 3D Structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:016230338</ref><ref group="xtra">PMID:016673263</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Thrombin]]
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[[Category: Bock PE]]
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[[Category: Bock, P E.]]
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[[Category: Bode W]]
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[[Category: Bode, W.]]
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[[Category: Friedrich R]]
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[[Category: Friedrich, R.]]
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[[Category: Fuentes-Prior P]]
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[[Category: Fuentes-Prior, P.]]
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[[Category: Kawabata S]]
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[[Category: Kawabata, S.]]
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[[Category: Panizzi P]]
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[[Category: Panizzi, P.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Prothrombin activator]]
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Current revision

Staphylocoagulase bound to bovine thrombin

PDB ID 2a1d

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