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3pgl

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[[Image:3pgl.png|left|200px]]
 
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{{STRUCTURE_3pgl| PDB=3pgl | SCENE= }}
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==Crystal structure of human small C-terminal domain phosphatase 1 (Scp1) bound to rabeprazole==
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<StructureSection load='3pgl' size='340' side='right'caption='[[3pgl]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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===Crystal structure of human small C-terminal domain phosphatase 1 (Scp1) bound to rabeprazole===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pgl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PGL FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21348431}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RZX:2-[(R)-{[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYL}SULFINYL]-1H-BENZIMIDAZOLE'>RZX</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgl OCA], [https://pdbe.org/3pgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pgl RCSB], [https://www.ebi.ac.uk/pdbsum/3pgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgl ProSAT]</span></td></tr>
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[[3pgl]] is a 2 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGL OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTDS1_HUMAN CTDS1_HUMAN] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.<ref>PMID:12721286</ref> <ref>PMID:15681389</ref>
==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021348431</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoprotein phosphatase]]
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[[Category: Large Structures]]
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[[Category: Burstein, G.]]
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[[Category: Burstein G]]
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[[Category: Cho, E J.]]
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[[Category: Cho EJ]]
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[[Category: Siegel, D.]]
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[[Category: Siegel D]]
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[[Category: Zhang, M.]]
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[[Category: Zhang M]]
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[[Category: Zhang, Y.]]
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[[Category: Zhang Y]]
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[[Category: Ctd phosphatase]]
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[[Category: Had family]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Insertion domain]]
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[[Category: Neuronal silencer]]
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Current revision

Crystal structure of human small C-terminal domain phosphatase 1 (Scp1) bound to rabeprazole

PDB ID 3pgl

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