1cw3

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[[Image:1cw3.png|left|200px]]
 
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{{STRUCTURE_1cw3| PDB=1cw3 | SCENE= }}
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==HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE COMPLEXED WITH NAD+ AND MN2+==
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<StructureSection load='1cw3' size='340' side='right'caption='[[1cw3]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
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===HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE COMPLEXED WITH NAD+ AND MN2+===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1cw3]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CW3 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10631996}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cw3 OCA], [https://pdbe.org/1cw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cw3 RCSB], [https://www.ebi.ac.uk/pdbsum/1cw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cw3 ProSAT]</span></td></tr>
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[[1cw3]] is a 8 chain structure of [[Aldehyde dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW3 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDH2_HUMAN ALDH2_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/1cw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cw3 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aldehyde dehydrogenase|Aldehyde dehydrogenase]]
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:010631996</ref><ref group="xtra">PMID:011173462</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hurley, T D.]]
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[[Category: Large Structures]]
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[[Category: Ni, L.]]
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[[Category: Hurley TD]]
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[[Category: Weiner, H.]]
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[[Category: Ni L]]
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[[Category: Zhou, J.]]
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[[Category: Weiner H]]
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[[Category: Dinucleotide fold]]
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[[Category: Zhou J]]
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[[Category: Oxidoreductase]]
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Current revision

HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE COMPLEXED WITH NAD+ AND MN2+

PDB ID 1cw3

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