2awg

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[[Image:2awg.png|left|200px]]
 
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{{STRUCTURE_2awg| PDB=2awg | SCENE= }}
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==Structure of the PPIase domain of the Human FK506-binding protein 8==
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<StructureSection load='2awg' size='340' side='right'caption='[[2awg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===Structure of the PPIase domain of the Human FK506-binding protein 8===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2awg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AWG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2awg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awg OCA], [https://pdbe.org/2awg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2awg RCSB], [https://www.ebi.ac.uk/pdbsum/2awg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2awg ProSAT]</span></td></tr>
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[[2awg]] is a 1 chain structure of [[FK506 binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWG OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKBP8_HUMAN FKBP8_HUMAN] Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.<ref>PMID:12510191</ref> <ref>PMID:16176796</ref> <ref>PMID:15757646</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aw/2awg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2awg ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[FK506 binding protein|FK506 binding protein]]
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith C]]
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[[Category: Davis, T.]]
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[[Category: Bochkarev A]]
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[[Category: Dhe-Paganon, S.]]
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[[Category: Davis T]]
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[[Category: Edwards, A.]]
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[[Category: Dhe-Paganon S]]
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[[Category: Finerty, P.]]
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[[Category: Edwards A]]
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[[Category: Mackenzie, F.]]
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[[Category: Finerty P]]
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[[Category: Newman, E M.]]
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[[Category: Mackenzie F]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Newman EM]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Walker, J R.]]
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[[Category: Walker JR]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Bcl-2 inhibitor]]
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[[Category: Fkbp-type]]
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[[Category: Ppiase]]
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[[Category: Sgc]]
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[[Category: Shh signalling antagonist]]
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[[Category: Signaling protein inhibitor]]
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[[Category: Structural genomics consortium]]
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Current revision

Structure of the PPIase domain of the Human FK506-binding protein 8

PDB ID 2awg

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Proteopedia Page Contributors and Editors (what is this?)

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