1t41
From Proteopedia
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| - | [[Image:1t41.png|left|200px]] | ||
| - | + | ==Crystal structure of human aldose reductase complexed with NADP and IDD552== | |
| - | + | <StructureSection load='1t41' size='340' side='right'caption='[[1t41]], [[Resolution|resolution]] 1.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1t41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T41 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ID5:[5-FLUORO-2-({[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]AMINO}CARBONYL)PHENOXY]ACETIC+ACID'>ID5</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t41 OCA], [https://pdbe.org/1t41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t41 RCSB], [https://www.ebi.ac.uk/pdbsum/1t41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t41 ProSAT]</span></td></tr> |
| - | [[1t41]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t4/1t41_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t41 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Aldose | + | *[[Aldose reductase 3D structures|Aldose reductase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Chevrier | + | [[Category: Large Structures]] |
| - | [[Category: Hazemann | + | [[Category: Chevrier B]] |
| - | [[Category: Joachimiak | + | [[Category: Hazemann I]] |
| - | [[Category: Karplus | + | [[Category: Joachimiak A]] |
| - | [[Category: Mitschler | + | [[Category: Karplus M]] |
| - | [[Category: Podjarny | + | [[Category: Mitschler A]] |
| - | [[Category: Ruiz | + | [[Category: Podjarny A]] |
| - | [[Category: Schneider | + | [[Category: Ruiz F]] |
| - | + | [[Category: Schneider T]] | |
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Current revision
Crystal structure of human aldose reductase complexed with NADP and IDD552
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