1zs5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1zs5" [edit=sysop:move=sysop])
Current revision (08:12, 15 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1zs5.png|left|200px]]
 
-
{{STRUCTURE_1zs5| PDB=1zs5 | SCENE= }}
+
==Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association==
-
 
+
<StructureSection load='1zs5' size='340' side='right'caption='[[1zs5]]' scene=''>
-
===Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1zs5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZS5 FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
==About this Structure==
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MIB:(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE'>MIB</scene></td></tr>
-
[[1zs5]] is a 1 chain structure of [[Histone acetyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZS5 OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zs5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zs5 OCA], [https://pdbe.org/1zs5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zs5 RCSB], [https://www.ebi.ac.uk/pdbsum/1zs5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zs5 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KAT2B_HUMAN KAT2B_HUMAN] Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.<ref>PMID:8684459</ref> <ref>PMID:9707565</ref> <ref>PMID:10675335</ref> <ref>PMID:23932781</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zs/1zs5_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zs5 ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Histone acetyltransferase|Histone acetyltransferase]]
+
*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
-
[[Category: Histone acetyltransferase]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Godbole, S.]]
+
[[Category: Large Structures]]
-
[[Category: Muller, M.]]
+
[[Category: Godbole S]]
-
[[Category: Sanchez, R.]]
+
[[Category: Muller M]]
-
[[Category: Yan, S.]]
+
[[Category: Sanchez R]]
-
[[Category: Zeng, L.]]
+
[[Category: Yan S]]
-
[[Category: Zhou, M.]]
+
[[Category: Zeng L]]
-
[[Category: Bromodomain]]
+
[[Category: Zhou M]]
-
[[Category: Histone-acetyltransferase]]
+
-
[[Category: Nmr-structure chemical ligand]]
+
-
[[Category: Transferase]]
+

Current revision

Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association

PDB ID 1zs5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zs5"
Personal tools