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1a3b
From Proteopedia
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| - | [[Image:1a3b.png|left|200px]] | ||
| - | + | ==COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1== | |
| - | + | <StructureSection load='1a3b' size='340' side='right'caption='[[1a3b]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1a3b]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A3B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T29:TRI166+(BIFUNCTIONAL+BORONATE+INHIBITOR)'>T29</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a3b OCA], [https://pdbe.org/1a3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a3b RCSB], [https://www.ebi.ac.uk/pdbsum/1a3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a3b ProSAT]</span></td></tr> |
| - | [[1a3b]] | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HIR2_HIRME HIR2_HIRME] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a3b_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a3b ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Hirudin|Hirudin]] | + | *[[Hirudin 3D structures|Hirudin 3D structures]] |
| - | *[[Thrombin|Thrombin]] | + | *[[Thrombin 3D Structures|Thrombin 3D Structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Hirudo medicinalis]] | [[Category: Hirudo medicinalis]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Deadman | + | [[Category: Deadman J]] |
| - | [[Category: Dodson | + | [[Category: Dodson G]] |
| - | [[Category: Elgendy | + | [[Category: Elgendy S]] |
| - | [[Category: Freyssinet | + | [[Category: Freyssinet JH]] |
| - | [[Category: Goodwin | + | [[Category: Goodwin CA]] |
| - | [[Category: Green | + | [[Category: Green D]] |
| - | [[Category: Kakkar | + | [[Category: Kakkar VV]] |
| - | [[Category: Scully | + | [[Category: Scully MF]] |
| - | [[Category: Skordalakes | + | [[Category: Skordalakes E]] |
| - | + | ||
Current revision
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1
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