1z3n

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[[Image:1z3n.png|left|200px]]
 
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{{STRUCTURE_1z3n| PDB=1z3n | SCENE= }}
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==Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom==
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<StructureSection load='1z3n' size='340' side='right'caption='[[1z3n]], [[Resolution|resolution]] 1.04&Aring;' scene=''>
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===Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1z3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3N FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15857120}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3NA:{3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC+ACID'>3NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3n OCA], [https://pdbe.org/1z3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3n RCSB], [https://www.ebi.ac.uk/pdbsum/1z3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3n ProSAT]</span></td></tr>
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[[1z3n]] is a 1 chain structure of [[Aldose Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3N OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3n ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aldose Reductase|Aldose Reductase]]
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015857120</ref><references group="xtra"/>
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[[Category: Aldehyde reductase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dicioccio, A T.]]
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[[Category: Large Structures]]
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[[Category: Geraci, L S.]]
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[[Category: Dicioccio AT]]
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[[Category: Gunn, D E.]]
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[[Category: Geraci LS]]
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[[Category: Jacot, J L.]]
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[[Category: Gunn DE]]
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[[Category: Jones, J H.]]
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[[Category: Jacot JL]]
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[[Category: Jones, M L.]]
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[[Category: Jones JH]]
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[[Category: Mitschler, A.]]
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[[Category: Jones ML]]
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[[Category: Petrova, T.]]
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[[Category: Mitschler A]]
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[[Category: Podjarny, A D.]]
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[[Category: Petrova T]]
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[[Category: Sawicki, D R.]]
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[[Category: Podjarny AD]]
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[[Category: Sredy, J.]]
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[[Category: Sawicki DR]]
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[[Category: Zandt, M C.Van.]]
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[[Category: Sredy J]]
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[[Category: Lidorestat]]
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[[Category: Van Zandt MC]]
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[[Category: Nadp+]]
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[[Category: Oxidoreductase]]
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Current revision

Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom

PDB ID 1z3n

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OCA

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