1dam

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[[Image:1dam.png|left|200px]]
 
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{{STRUCTURE_1dam| PDB=1dam | SCENE= }}
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==DETHIOBIOTIN SYNTHETASE COMPLEXED WITH DETHIOBIOTIN, ADP, INORGANIC PHOSPHATE AND MAGNESIUM==
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<StructureSection load='1dam' size='340' side='right'caption='[[1dam]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===DETHIOBIOTIN SYNTHETASE COMPLEXED WITH DETHIOBIOTIN, ADP, INORGANIC PHOSPHATE AND MAGNESIUM===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1dam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DAM FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9865950}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DTB:6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC+ACID'>DTB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dam OCA], [https://pdbe.org/1dam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dam RCSB], [https://www.ebi.ac.uk/pdbsum/1dam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dam ProSAT]</span></td></tr>
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[[1dam]] is a 1 chain structure of [[Dethiobiotin synthetase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DAM OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BIOD1_ECOLI BIOD1_ECOLI] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. Only CTP can partially replace ATP while diaminobiotin is only 37% as effective as 7,8-diaminopelargonic acid.<ref>PMID:4892372</ref> <ref>PMID:4921568</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/1dam_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dam ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Dethiobiotin synthetase|Dethiobiotin synthetase]]
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*[[Dethiobiotin synthetase 3D structures|Dethiobiotin synthetase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009865950</ref><references group="xtra"/>
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__TOC__
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[[Category: Dethiobiotin synthase]]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Gibson, K J.]]
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[[Category: Large Structures]]
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[[Category: Kaeck, H.]]
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[[Category: Gibson KJ]]
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[[Category: Lindqvist, Y.]]
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[[Category: Kaeck H]]
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[[Category: Sandmark, J.]]
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[[Category: Lindqvist Y]]
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[[Category: Schneider, G.]]
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[[Category: Sandmark J]]
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[[Category: Atp-binding]]
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[[Category: Schneider G]]
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[[Category: Biotin biosynthesis]]
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[[Category: Ligase]]
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[[Category: Magnesium]]
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[[Category: Phosphoryl transfer]]
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Current revision

DETHIOBIOTIN SYNTHETASE COMPLEXED WITH DETHIOBIOTIN, ADP, INORGANIC PHOSPHATE AND MAGNESIUM

PDB ID 1dam

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