1q8r

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[[Image:1q8r.png|left|200px]]
 
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{{STRUCTURE_1q8r| PDB=1q8r | SCENE= }}
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==Structure of E.coli RusA Holliday junction resolvase==
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<StructureSection load='1q8r' size='340' side='right'caption='[[1q8r]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Structure of E.coli RusA Holliday junction resolvase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q8r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q8R FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14656440}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.899&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q8r OCA], [https://pdbe.org/1q8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q8r RCSB], [https://www.ebi.ac.uk/pdbsum/1q8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q8r ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1q8r]] is a 2 chain structure of [[Resolvase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q8R OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/RUSA_ECOLI RUSA_ECOLI] Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/1q8r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q8r ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Resolvase|Resolvase]]
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*[[Resolvase 3D structures|Resolvase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:014656440</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Baker, P J.]]
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[[Category: Large Structures]]
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[[Category: Bolt, E L.]]
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[[Category: Baker PJ]]
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[[Category: Leonard, P.]]
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[[Category: Bolt EL]]
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[[Category: Lloyd, R G.]]
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[[Category: Leonard P]]
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[[Category: Muranova, T A.]]
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[[Category: Lloyd RG]]
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[[Category: Pasquo, A.]]
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[[Category: Muranova TA]]
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[[Category: Rafferty, J B.]]
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[[Category: Pasquo A]]
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[[Category: Rice, D W.]]
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[[Category: Rafferty JB]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Rice DW]]
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[[Category: Sharples, G J.]]
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[[Category: Sedelnikova SE]]
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[[Category: Chorismate mutase-like fold]]
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[[Category: Sharples GJ]]
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[[Category: Extended mixed beta sheet]]
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[[Category: Hydrolase]]
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[[Category: Recombination]]
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Current revision

Structure of E.coli RusA Holliday junction resolvase

PDB ID 1q8r

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