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2rkc

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[[Image:2rkc.png|left|200px]]
 
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{{STRUCTURE_2rkc| PDB=2rkc | SCENE= }}
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==Crystal structure of the measles virus hemagglutinin==
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<StructureSection load='2rkc' size='340' side='right'caption='[[2rkc]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===Crystal structure of the measles virus hemagglutinin===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RKC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_018026116}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rkc OCA], [https://pdbe.org/2rkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rkc RCSB], [https://www.ebi.ac.uk/pdbsum/2rkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rkc ProSAT]</span></td></tr>
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[[2rkc]] is a 1 chain structure of [[Hemagglutinin]] with sequence from [http://en.wikipedia.org/wiki/Measles_virus Measles virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKC OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_MEASE HEMA_MEASE] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.<ref>PMID:9811778</ref>
==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018026116</ref><references group="xtra"/>
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__TOC__
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[[Category: Measles virus]]
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</StructureSection>
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[[Category: Colf, L A.]]
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[[Category: Large Structures]]
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[[Category: Garcia, K C.]]
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[[Category: Measles morbillivirus]]
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[[Category: Juo, Z S.]]
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[[Category: Colf LA]]
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[[Category: Envelope protein]]
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[[Category: Garcia KC]]
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[[Category: Hemagglutinin]]
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[[Category: Juo ZS]]
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[[Category: Measles virus]]
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[[Category: Membrane]]
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[[Category: Transmembrane]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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Current revision

Crystal structure of the measles virus hemagglutinin

PDB ID 2rkc

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