1fgj

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[[Image:1fgj.gif|left|200px]]<br /><applet load="1fgj" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1fgj, resolution 2.8&Aring;" />
 
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'''X-RAY STRUCTURE OF HYDROXYLAMINE OXIDOREDUCTASE'''<br />
 
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==Overview==
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==X-RAY STRUCTURE OF HYDROXYLAMINE OXIDOREDUCTASE==
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The 2.8 A crystal structure of hydroxylamine oxidoreductase of a nitrifying chemoautotrophic bacterium, Nitrosomonas europaea, is described. Twenty-four haems lie in the centre bottom of the trimeric molecule, localized in four clusters within each monomer. The haem clusters within the trimer are aligned to form a ring that has inlet and outlet sites. The inlet is occupied by a novel haem, P460, and there are two possible outlet sites per monomer formed by paired haems lying within a cavity or cleft on the protein surface. The structure suggests pathways by which electron transfer may occur through the precisely arranged haems and provides a framework for the interpretation of previous and future biochemical and genetic observations.
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<StructureSection load='1fgj' size='340' side='right'caption='[[1fgj]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1fgj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FGJ FirstGlance]. <br>
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1FGJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea] with <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=HEC:'>HEC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hydroxylamine_oxidase Hydroxylamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.4 1.7.3.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FGJ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fgj OCA], [https://pdbe.org/1fgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fgj RCSB], [https://www.ebi.ac.uk/pdbsum/1fgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fgj ProSAT]</span></td></tr>
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The 2.8 A structure of hydroxylamine oxidoreductase from a nitrifying chemoautotrophic bacterium, Nitrosomonas europaea., Igarashi N, Moriyama H, Fujiwara T, Fukumori Y, Tanaka N, Nat Struct Biol. 1997 Apr;4(4):276-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9095195 9095195]
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</table>
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[[Category: Hydroxylamine oxidase]]
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== Function ==
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[https://www.uniprot.org/uniprot/HAO_NITEU HAO_NITEU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fg/1fgj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fgj ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Nitrosomonas europaea]]
[[Category: Nitrosomonas europaea]]
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[[Category: Single protein]]
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[[Category: Igarashi N]]
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[[Category: Igarashi, N.]]
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[[Category: Moriyama H]]
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[[Category: Moriyama, H.]]
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[[Category: Tanaka N]]
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[[Category: Tanaka, N.]]
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[[Category: HEC]]
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[[Category: HEM]]
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[[Category: nitrification]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:38:25 2008''
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Current revision

X-RAY STRUCTURE OF HYDROXYLAMINE OXIDOREDUCTASE

PDB ID 1fgj

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