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1qq2

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[[Image:1qq2.png|left|200px]]
 
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{{STRUCTURE_1qq2| PDB=1qq2 | SCENE= }}
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==CRYSTAL STRUCTURE OF A MAMMALIAN 2-CYS PEROXIREDOXIN, HBP23.==
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<StructureSection load='1qq2' size='340' side='right'caption='[[1qq2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF A MAMMALIAN 2-CYS PEROXIREDOXIN, HBP23.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qq2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QQ2 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10535922}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qq2 OCA], [https://pdbe.org/1qq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qq2 RCSB], [https://www.ebi.ac.uk/pdbsum/1qq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qq2 ProSAT]</span></td></tr>
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[[1qq2]] is a 2 chain structure of [[Peroxiredoxin]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQ2 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRDX1_RAT PRDX1_RAT] Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/1qq2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qq2 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Peroxiredoxin|Peroxiredoxin]]
*[[Peroxiredoxin|Peroxiredoxin]]
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*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:010535922</ref><ref group="xtra">PMID:016307478</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Abe, Y.]]
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[[Category: Abe Y]]
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[[Category: Hakoshima, T.]]
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[[Category: Hakoshima T]]
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[[Category: Hirotsu, S.]]
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[[Category: Hirotsu S]]
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[[Category: Hori, H.]]
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[[Category: Hori H]]
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[[Category: Nagahara, N.]]
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[[Category: Nagahara N]]
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[[Category: Nishino, T.]]
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[[Category: Nishino T]]
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[[Category: Okada, K.]]
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[[Category: Okada K]]
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[[Category: Oxidoreductase]]
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[[Category: Thioredoxin fold]]
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Current revision

CRYSTAL STRUCTURE OF A MAMMALIAN 2-CYS PEROXIREDOXIN, HBP23.

PDB ID 1qq2

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